Blood clot dissolving agent



Blood clots are masses of blood cells that have clumped together because of disease or injury. In cases of damage, blood platelets (roundish disks associated with clotting found in mammal blood) mass (gather together) to stop bleeding. The platelets release clot-promoting chemicals and cause a clot to form.

Blood Clots

A blood clot in a vessel is called a thrombus, and it is called an embolus when part of it detaches and travels through the bloodstream, where it can lodge in a blood vessel and block blood flow. A thrombus can form where the body has been injured, where blood vessels are damaged by arteriosclerosis (hardening and/or narrowing of the arteries), or where blood stagnates (chronic bedrest can cause blood to stagnate, or pool, in one location). The thrombus can then block ever greater portions of the blood vessel. Blood flow can become blocked when a blood vessel gets obstructed by blood clots or other foreign matter in the bloodstream. Foreign matter could include air bubbles, fat globules from a broken bone, or fatty sub-stances accumulating on the inside wall of an artery (arteriosclerosis). As blood flow beyond the clot of blood or foreign matter is reduced or cut off, the part of the body thus deprived of oxygen may become damaged. If the brain becomes damaged, a stroke may result. If the heart muscle becomes damaged, a heart attack may result.

Over half of the cardiovascular (heart and blood vessel)-related deaths in the United States are caused by heart attacks, known as acute myocardial infarctions (MI). Strokes, known as cerebrovascular accidents (CVA), are the third-ranking cause of death in the United States (after heart disease and cancer). A clot that stops blood flow to the brain causes 80 percent of all strokes.

New Medicines Dissolve Clots

Many strategies have been developed to prevent these deposits from forming in patients who are prone to them. One approach is to use anti-coagulants (substances that prevent the blood-clotting factors in the blood from becoming active). Anticoagulants—including aspirin, warfarin, and heparin—thin the blood (reduce the stickiness of blood), which helps prevent clots from forming in the first place.

Until recently, however, there were very few therapies that were able to break down clots that had already formed. Scientists have now developed several substances that can reduce existing clots. These new treatments were first used for heart attack patients, and have recently being used to treat stroke victims.

This process of dissolving blood clots that already exist is called thrombolysis. Three groups of thrombolytic agents are available, including enzymes, which act directly upon the fibrin strands within the clot, plasma activator agents, which increase plasma activator activity, and plasminogen activators, such as streptokinase, urokinase, and tissue plasminogen. All these drugs digest clots by increasing the amount of plasmin (plasmin dissolves clots) in the blood. To produce plasmin, the substance plasminogen must first be activated. Plasminogen is converted into plasmin by certain enzymes known as plasminogen activators.

Streptokinase has been used since about 1960. Researchers use streptococci bacteria to produce this drug. Although streptokinase is the least expensive activator, some negative side effects, such as immune responses, have been experienced by patients. Urokinase is found naturally in humans, especially in the urine. Thus, no negative immune response is associated with its use. This therapy is usually administered in small doses and combined with other drugs, because it is difficult to purify, and therefore rather expensive.

Tissue Plasminogen Activator Aids Heart Attack and Stroke Victims

Tissue plasminogen activator (tPA) is currently the most expensive drug for dissolving blood clots. It is unique because it activates only fibrin-bound plasminogen and thus targets the clot site. tPA in human blood is produced in very small amounts by vascular endothelial cells. Since about 1980, when tPA was first purified from human uterine tissue, it has enjoyed widespread use among American physicians. Lately, researchers have even used cloning technology to recombine the genes that encode human tPA. Cloning is transferring the genetic material from one organism into another organism, such as a virus or bacteria, which is called a host. The host reproduces, new generations of offspring, called clones, that are identical genetically. Scientists have cloned hamster genes to produce tPA in large quantities. This should help make the drug more affordable.

Each of these thrombolytic agents shows great promise in reducing the severity of heart attacks. More recent studies of using tPA for certain stroke victims show significant reduction of brain injury if given within three to six hours of the start of the stroke. This is very exciting, because until now no treatment has served to limit the damage caused by stroke. However, studies are ongoing to define which patients will benefit from tPA, because tPA given to the wrong type of stroke patient could start an episode of severe bleeding.

[See also Gene ]



User Contributions:

edward griffee
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Oct 3, 2007 @ 2:02 am
HOW DO I DISSOLVE A BLOOD CLOT? I HAVE HAD STABLE PAD FOR THE PAST NINE YRARS. NEITHER THE BLOOD NOR PAD CAUSE ME PAIN EXCEPT WHEN I AM ON THE TREADMILL
bob morgan
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Mar 6, 2008 @ 11:11 am
Can Nitric Oxide supplements be used when there is an existing blood clot?
al lacy/s.f.,ca.94111
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Jun 23, 2008 @ 10:22 pm
How do I get a security code???

there is nothing on the page to comment qbout??!!

can you advise me, on how to dissolve a blood clot in the
liver?? I am a 65yr Cauc. male, whose stomach looks like it is "8 1/2 months pregnant. Reply to: mrallacy@
znet.com. Any help would be appreciated as they only give me "weeks to a few months to live," at Ft. Miley,
San Francisco,CA. Thank you. Al L.
K.Rajyalakshmi
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Jul 4, 2008 @ 1:01 am
How can i dissolve blood clot in brain .Is it possible to dissolve
WILLIAM J CLEMONS
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Sep 10, 2008 @ 12:12 pm
Having discovered blood clots in both right and left upper legs in July, I have been informed that there is not way of dissovling such clots and that I will have to just "live with it". Now I discover taht there are possible medicines to dissolve clots.

Would you please inform me of any opportunities. Age 77 - retired - hoping to be able to be able to work part time in tax preparation -sold my practice in 2003 after 48 yrs - but these clots present a problem.
thank you very much
Wallace Larsen
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Feb 5, 2009 @ 3:15 pm
I have had 2 blood clots in lower leg below the back of the knee. The Dr. has me on comundon and I still get some pain ( flibitis) Is there any way to excercise or get my leg back to normal. I wear support socks and that helps.
Thank You,
Wallace Larsen
Natalie Brand
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Mar 5, 2009 @ 9:09 am
My mother is in the hosp with a blood clot. They have been giving her shots in the stomache to disolve the clot, and a blood thinner. They say another cat scan isn't necessary for 3 months because the clot should be stable with the 2 precautions they have already taken. Is this something to be concerned about?
wayenbam sobhachandra
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Mar 25, 2009 @ 5:05 am
please analyse something whether plant serine protease can be use in clot dissolution
khanyi
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Jul 17, 2009 @ 5:05 am
HOW CAN I GET HOLD OF THE ABOVE TALKED ABOUT MEDICATION TO HELP DISSOLVE CLOT ON THE CALF OF MY LEGS
Jerry Thiel
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Aug 1, 2009 @ 7:19 pm
I have blood clots in my left leg. What can I use to dissolve these clots. IAM using cumidin.

Thanks-Jerry
Rod Maurino
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Oct 30, 2009 @ 2:14 pm
My doctor is convinced that acenocumarol not directly act over blood clots but intaken that blood thinner medicine, under his control obviously, will help to form an blood enviroment highly favorable to dissolve clots. Both, medicine and life interact in help of survival. Regards
n hadley
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Dec 20, 2009 @ 3:15 pm
AFTER RETURNING FROM MEXICO ON VACATION 2 WEEKS AGO MY LEG SWELLED UP ON THE PLANE. I WENT TO MY DOCTOR AND HOSPITAL. I WAS TOLD THAT I HAVE A BLOOD CLOT IN MY LOWER CALF. IT HAS BEEN TWO WEEKS WITH MY LEG UP AND IT SEEMS TO BE GETTING WORSE. I CAN HARDLY WALK AND IT IS PAINFUL. I AM TAKING CUMADIN AND IT IS BEING MONITORED.
CAN I DO ANYTHING ELSE TO SPEED UP THE RECOVERY? IS WHAT I AM DOING THE RIGHT THING?

THANK YOU FOR YOUR HELP.
Johnny Fitness
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Jun 15, 2010 @ 11:11 am
Has anyone heard of or used Nattokinase to dissolve a blood clot? I am reading favorable studies of it's use and am thinking of trying it. I have been on Coumadin for over a year now and the clot is not showing much change after a CAT scan of my abdomen. What is up with modern medicine? I was put on rat poison that hasn't even worked. A little archaic if you ask me.
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Jul 21, 2010 @ 7:07 am
One of my dear friends son(only 16 Years old)had bleeding in veins next to spinal cord. The affect veins operations has been carried out successfully but the clots on the veins are still sticking to them causing brain message blockades in speech or may be sound, sight too. There is some sensation in limbs when pinched.
Dissolving those clots which are sticking to delicate veins is an issue with the medical team. What advice can any body give? Is there some Homeopathic medecines to dissolve those clots. Please send the reply asap.
Jeanine
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Jul 29, 2010 @ 3:15 pm
Anyone dealing with blood clots should look into Nattokinase or Lumbrokinase.
They have powerfull fibrinolytic activity that can actually dissolve clots,
(which wayfarin cannot) as well as being much safer than coumadin/wayfarin.
Research it on PubMed. Try the NSKD Nattokinase, or Lumbrokinase. These are
over the counter products you can find online. If you are prone to cerebral
BLEEDS be carefull, do your research, perhaps consult a cutting edge holistic
practitioner/Dr. who uses Nattokinase etc, and if you use NK, DO NOT combine
with aspirin or other antithrombotics, natural or pharmaceutical. That caution
would apply even more so to wayfarin/coumadin, of course.
Roy
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Feb 10, 2011 @ 3:15 pm
Any hope that this could help people suffering from Peyronie's disease?
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Apr 18, 2011 @ 10:22 pm
In second week of this month I had a brain stroke and due to that I was not able to hold the mouse properly. I immediately consulted the doctor and I have been given the Tab : TELMEGUARD for controling pressure and Asprin for thinning the blood and another one tab. for bringing down the cholostrol level. My cholostrol is 226. I got some clots in brain and two vessels meant for bood supply to brain are blocked 20% and 50%. Please advise me what I should do and what precaution I should take. Which type of food should be avoided. Please advise me. Thanks.
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Apr 23, 2011 @ 7:19 pm
My dad is 62 and has a blood clot in his brain besides aaprin what can help him he also has diabetes. Is there a food that helps or vitamins anything?
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Jul 7, 2011 @ 1:01 am
dissolve blood clots naturally also, carotid arteries
sindhu
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Aug 14, 2011 @ 11:11 am
HI, my friend got hit heavily with marble slap before five months, doctor diagnised as two blood clots formed in brain, now he is under medication for four months, will it lead to death , he is just 21 years
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Sep 6, 2011 @ 6:18 pm
how do you streptokinase will digest fibrin only and not good tissue
grace
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Dec 7, 2011 @ 3:15 pm
google article "exercise-can-help-dissolve-blood-clots." (WebMD may 8, 2003)this article is on study showing the human body produces t-PA enough to dissolve blood clots by exercising (e.g. 45 minutes walk /day). the good thing with enabling body to heal itself is that one can never overdose nor suffer from side effects. if you can't walk, just move your legs like you are scrubbing floor alternately back and forth while seated as vigorously as possible (i do that while studying as i study for long hours with a few minutes of break). so mobility can also keep the blood circulating better which keeps it from pooling, a great condition for blood clots (couch potatoes take note).
gina
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Dec 9, 2011 @ 7:19 pm
Is it possible to dissolve a clot inside a metal stent that was placed 6 months ago to avoid another surgical procedure? I've read so many articles but none that mention a clot within a stent. Thank you
Steven
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Jan 23, 2012 @ 11:23 pm
My son is 23 years old a former offensive lineman for a PAC 12 football team. He has factor 5 blood type and now has just had his 2nd M I clot in his led. Is there any thing in the future beside Coumadin that can be used. I know that this a hard question not knowing his medical history but he is now going to be on it for the foreseeable future up to 5 years.
bstacey
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Feb 24, 2012 @ 12:00 am
For lowering platelet count and thinning blood -red wine if you use alcohol.
To keep fats emulsified in the blood stream allowing our organs/supplements more time to metabolize the fats-lethicin
Vitamin E and Omega 3 thin blood.Omega-3 with EPA and DHA are best for brain health and repair..
Nattokinase efficacy comes from vitamin K-2 found in many Asian "brewed"foods. k-2 is available as a supplement.
EDTA calcium di-sodium works well/suppositories to dissolve plaque and calcium buildup along with removal of heavy metals.Use nutritional supplements and timing with EDTA..Read/Google about chelation and detoxification.
EDTA magnesium di-potassium works well but is expensive.IV protocol or suppositories.
Suppositories easier to tolerate.Again use with nutritional supplementation.
Take chlorella first thing in the morning for optimum detoxification
sonia
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Mar 9, 2012 @ 11:23 pm
i am 38 years old. Two montbs before, suddenly i got a headache and the doctors discovered a blood clot in the brain. i was hospialised for 15 days. now, i am taking medicine to thin my blood ecosprin. but i am having my headache again. that is why i am afraid of having this clot again. please reply me and give me suggestion to get rid of this painful disease. is it possible of having this clot again. than you.
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Mar 29, 2012 @ 8:08 am
My father got accident. At that time he got a wound on left side fore head. We had taken c.t scan, it reveals the blood clot in left side of brain at above of the wound. What medicines are used to cure that blood clot in the brain. Please reply to me. .
Manny
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May 22, 2012 @ 10:22 pm
Dr Who,
I have a lingering pain on top of my head that started about 2 or 3 weeks ago, now it's moving to the right side of my head; could that be a sign of migrating blood cloth. It is not an intense pain , but enough to bother me and I'm starting to get worried for my only child has just turned twelve. I'm 61 years old and had a high blood condition for over 10 years but it is under control w/ medication. I'm on 20 mg Benicar for about a year now. Your professional opinion is highly anticipated.

Thank you very much.
Bex
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Jun 6, 2012 @ 8:20 pm
My brother is in hospital with a bloodclot in his pelvis. They are giving him shots in the stomach daily. Is there any other treatment to disolve the clot? He also has Spinal Musclar Astrophy Type 2 to make things worse... Any help you could offer would be greatly appreciated.
kristi
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Jun 3, 2013 @ 11:11 am
My son has Hodgkins and developed chest pains when the gave him his last chemo. He started having swelling in his arm week later. After scan realized large blood clot on the same side with port. My son now gives himself shots twice daily. Is there anything else they can give him to dissovlve clots we are going back for scan on his other arm today because he has pain now in it too.
jhune buela
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Oct 24, 2014 @ 8:08 am
i have a friend who is diagnosed for abdominal aortic blood clot, can you send some advise what medicine can he use to dissolve blood clot? thank you so much
Nokuthula Masuku
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Dec 8, 2014 @ 3:03 am
I had a car accident two weeks ago and now I feel a hard thing in my stomach / bladder and the doctor said it's a blood clot and after an accident my urine was red and I don't know how to dissolve that blood clot.

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