Aureomycin
During and shortly following World War II (1939-1945), new "miracle drugs" revolutionized the medical treatment of infections. These new drugs included several types of substances found to have antibacterial (destructive to bacteria) and antiviral (destructive to viruses) properties. One of these classes of drugs was the tetracyclines. Tetracyclines are a family of antibiotics similar to penicillin that have shown themselves to be both nontoxic (nonpoisonous) and effective against a wide range of infections.
Duggar's Research
Aureomycin, the first of the tetracyclines, was discovered in 1948 by American botanist Benjamin Minge Duggar (1872-1956). Duggar was 76 years old at the time of his discovery. He had graduated from the Mississippi Agricultural and Mechanical College (Mississippi State College) and studied at Alabama's Polytechnic Institute and Harvard University. Duggar later became a professor of botany at the University of Missouri, Washington University, and the Missouri Botanical Garden. He did pioneering research on the tobacco mosaic virus and became widely known for his work with molds and fungi (a group of organisms, such as mushrooms, that lack chlorophyll, roots, stems, or leaves, and reproduce by spores).
Later, as a consultant to the Lederle Division of the American Cyanamid Company, Duggar turned to research on new antibacterial drugs. Although penicillin and streptomycin were being widely used to treat bacterial infections, a number of diseases and strains of bacteria were resistant to the treatments. Duggar focused his research on groups of molds found in soil. He tested more than 3,500 strains of molds before he had a success. In 1945 he tested a sample taken from soil at the University of Missouri campus. A golden-hued (colored) substance produced by the mold exhibited antibiotic properties. After extensive testing, he found it to be active against bacilli, staphylococci, and streptococci (all forms of bacteria). Duggar named the substance aureomycin, from the Latin word "aureus," meaning gold, and the Greek word "mykes," meaning fungus.
Aureomycin
Continued testing revealed that aureomycin was effective against 90 percent of bacteria-caused infections. In human trials, the medication was found to be effective against a wide range of infections with minimal side effects. Unlike penicillin and streptomycin, which had to be injected, aureomycin could be taken orally (by mouth). Aureomycin was also effective in treating diseases that did not respond to other antibiotics, such as trachoma, parrot fever, typhus, chlamydias, and mycoplasmas. It was also active against Rocky Mountain spotted fever, an infection which had spread throughout the United States. Caused by a microorganism called rickettsia and transmitted by a tick, the disease was fatal in one out of every five patients. For a time, aureomycin was added to livestock feed to prevent diseases in animals. This practice has been largely discontinued, however, because it breeds bacteria which are immune to the drugs.
Other tetracyclines include terramycin, achromycin and declomycin. Many medical experts consider tetracyclines to be the least toxic and most effective antibiotics next to penicillin. In certain patients, however, they can cause minor side-effects such as nausea, diarrhea, and tooth discoloration. Because the tetracyclines have been used so widely against a variety of diseases, several strains of bacteria have developed resistance to them. As a result, physicians often prescribe other antibiotics for common urinary tract and respiratory (having to do with the lungs and upper chest) infections.
Tobey, if you were the first kid in that life-and-death effort, Thanks!
They then mentioned that a new drug called Aureomycin should be worth trying; to be taken by mouth. Good news for my poor pincushion bottom. The effect seemed almost immediate. The swelling on my hand lost its pressure against the bandages. I delighted in squeezing the back of my hand and watching the pus stream out near my index finger. I could sense that the heat was off and the swellings becoming 'slacker'. Four days later I was discharged. Thanks to aureomycin I still have four limbs.
I am a retired college Instructor. I had a student that had the same disease and received the same operation when he was 13. He said that he was hospitalized all the time. He never finished my class.
If I was born four or five years later, I wouldn't have had my lung removed, and I wouldn't have had the disfigurement with all of its personal affects. I'm almost 78 and have to take three inhalants twice daily to breathe, but hey! I'm still alive!
I have carried the name of this medication in my memory all these years (70 years young)and thank the Lord for his blessing me with the life I have had.
For years afterwards I had bouts with strep throat but by the time I was about 25 it went totally away. Now at 85 I have had a bout with streptococcus from a wound infection. These experiences Ned to be made known because the golden drug still may have applications to humans as well as keeping animals healthy.